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KMID : 0606920090170040418
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Biomolecules & Therapeutics
2009 Volume.17 No. 4 p.418 ~ p.421
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Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE2 Production from LPS-Induced RAW 264.7 Cells
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Gurung Santosh Kumar
Lim Hyun
Kim Hyun-Pyo
Park Hae-Il
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Abstract
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Structural alterations of wogonin were conducted to observe the role of each functional group at the A-ring of wogonin on the inhibitory activities against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells. Serial deletion of the functional groups at the A-ring of wogonin exhibited low to comparable bioactivity. The present study validated that all the functional groups at the A-ring of wogonin are important factors to exhibit the optimum inhibitory activities.
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KEYWORD
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Structural alterations, Wogonin, PGE2 production, COX-2, Anti-inflammatory activity
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